External validation of the Fatty Liver Index and Lipid Accumulation Product indices , using 1 H - Magnetic Resonance Spectroscopy , to identify hepatic steatosis

نویسندگان

  • Daniel J Cuthbertson
  • Martin O Weickert
  • Daniel Lythgoe
  • Victoria S Sprung
  • Rebecca Dobson
  • Fariba Shoajee-Moradie
  • Margot Umpleby
  • Andreas F H Pfeiffer
  • E Louise Thomas
  • Jimmy D Bell
  • Helen Jones
  • Graham J Kemp
  • Daniel Cuthbertson
چکیده

Department of Obesity and Endocrinology, University Hospital Aintree, Liverpool; and Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool. Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire NHS Trust, Coventry; and Division of Metabolic & Vascular Health, Warwick Medical School, University of Warwick, Warwick. Cancer Research UK Liverpool Cancer Trials Unit, University of Liverpool Department of Diabetes and Metabolic Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford. Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany; and the Department of Endocrinology, Diabetes and Nutrition, Charité-University-Medicine Berlin, Germany. Metabolic and Molecular Imaging Group, MRC Clinical Sciences Centre, Imperial College London. Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool 8 Magnetic Resonance and Image Analysis Research Centre, and Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of a 10-week combined exercise training on new fatty liver markers in women with type 2 diabetes

Introduction: Fatty liver is a condition in people with type 2 diabetes mellitus (T2DM). The purpose of this study is to examine the effects of combined training on novel hepatic steatosis indices (fatty liver index (FLI), accumulation product (LAP), hepatic steatosis index (HSI), and Framingham steatosis index (FSI)) in women with type 2 diabetes. Methods: 35 female with type 2 diabetes wer...

متن کامل

Comparison of Liver Fat Indices for the Diagnosis of Hepatic Steatosis and Insulin Resistance

CONTEXT Hepatic steatosis, defined as increased hepatocellular lipid content (HCL), associates with visceral obesity and glucose intolerance. As exact HCL quantification by 1H-magnetic resonance spectroscopy (1H-MRS) is not generally available, various clinical indices are increasingly used to predict steatosis. OBJECTIVE The purpose of this study was to test the accuracy of NAFLD liver fat s...

متن کامل

Diagnostic accuracy and clinical utility of a new noninvasive index for hepatic steatosis in patients with hepatitis B virus infection

The aim of the present study was to construct a cost-effective noninvasive diagnostic index for prediction of hepatic steatosis in patients with hepatitis B virus(HBV) infection. From January 2011 to January 2015, a total of 364 consecutive subjects who underwent liver biopsies were enrolled. The Receiver-operating characteristic(ROC) curves and Obuchowski measure were constructed to evaluate t...

متن کامل

Non-alcoholic fatty liver disease in women with polycystic ovary syndrome: assessment of non-invasive indices predicting hepatic steatosis and fibrosis.

OBJECTIVE Insulin resistance contributes to the pathogenesis of both polycystic ovary syndrome (PCOS) and non-alcoholic fatty liver disease (NAFLD). The main aim of the present study was the evaluation of non-invasive indices of hepatic steatosis and fibrosis in PCOS women with or without metabolic syndrome (MetS). DESIGN In this cross-sectional study, three non-invasive indices for hepatic s...

متن کامل

Associations between Dietary Nutrient Intakes and Hepatic Lipid Contents in NAFLD Patients Quantified by 1H-MRS and Dual-Echo MRI

Dietary habits are crucial in the progression of hepatic lipid accumulation and nonalcoholic fatty liver disease (NAFLD). However, there are limited studies using ¹H-magnetic resonance spectroscopy (¹H-MRS) and dual-echo in-phase and out-phase magnetic resonance spectroscopy imaging (dual-echo MRI) to assess the effects of dietary nutrient intakes on hepatic lipid contents. In the present study...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016